Ralph T Schermuly Selected Research

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

2/2011	Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6.
1/2007	Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs.
4/2006	Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction.
9/2005	Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia.
12/2003	Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs.

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Ralph T Schermuly Research Topics

Disease

55	Pulmonary Hypertension 02/2022 - 09/2002
44	Hypoxia (Hypoxemia) 01/2022 - 12/2003
25	Pulmonary Arterial Hypertension 01/2022 - 07/2003
19	Vascular Remodeling 02/2021 - 02/2009
16	Fibrosis (Cirrhosis) 10/2019 - 09/2002
15	Familial Primary Pulmonary Hypertension 01/2022 - 09/2007
10	Inflammation (Inflammations) 01/2019 - 02/2009
8	Emphysema 01/2022 - 10/2011
7	Hypertrophy 01/2019 - 11/2008
6	Pulmonary Fibrosis (Fibrosing Alveolitis) 03/2022 - 12/2003
5	Chronic Obstructive Pulmonary Disease (COPD) 07/2020 - 06/2015
5	Lung Injury 10/2019 - 05/2008
5	Cardiomegaly (Heart Hypertrophy) 12/2013 - 01/2004
4	Idiopathic Pulmonary Fibrosis 01/2022 - 10/2010
4	Pneumonia (Pneumonitis) 10/2019 - 07/2003
4	Lung Diseases (Lung Disease) 10/2019 - 10/2010
4	Ventricular Remodeling 03/2018 - 02/2012
3	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2022 - 12/2003
3	Atherosclerosis 11/2020 - 12/2010
3	Heart Failure 01/2019 - 03/2012
3	Right Ventricular Hypertrophy 11/2017 - 04/2011
3	Hyperoxia 03/2017 - 02/2007
3	Acute Lung Injury 01/2017 - 12/2008
2	Bronchopulmonary Dysplasia 01/2018 - 02/2007
2	Vascular Diseases (Vascular Disease) 03/2017 - 11/2015
2	Edema (Dropsy) 01/2017 - 05/2008
2	Ischemia 01/2017 - 03/2009
2	Neointima 03/2016 - 05/2010
2	Hypertension (High Blood Pressure) 11/2015 - 02/2014
2	Aneurysm (Aneurysms) 03/2014 - 12/2013
2	Acidosis 01/2012 - 11/2009
2	Hypercapnia 01/2012 - 11/2009
2	Body Weight (Weight, Body) 06/2011 - 12/2003

Drug/Important Bio-Agent (IBA)

20	MonocrotalineIBA 02/2021 - 01/2004
9	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2004
9	NADPH Oxidases (NAD(P)H oxidase)IBA 07/2020 - 05/2004
8	Superoxides (Superoxide)IBA 01/2020 - 12/2003
8	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2018 - 12/2003
7	Bleomycin (Blenoxane)FDA LinkGeneric 03/2022 - 12/2003
7	SmokeIBA 01/2022 - 10/2011
6	Oxygen (Dioxygen)IBA 01/2020 - 12/2003
6	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 06/2013 - 02/2007
5	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022 - 02/2007
5	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 09/2002
5	Sildenafil Citrate (Viagra)FDA Link 01/2013 - 09/2002
5	Vasoconstrictor AgentsIBA 06/2011 - 07/2005
5	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidIBA 02/2011 - 12/2003
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 04/2011
4	Transcription Factors (Transcription Factor)IBA 01/2022 - 09/2008
4	Phosphotransferases (Kinase)IBA 01/2021 - 11/2008
4	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2021 - 05/2011
4	Semaxinib (SU5416)IBA 01/2021 - 09/2008
4	CollagenIBA 11/2018 - 12/2003
4	Biomarkers (Surrogate Marker)IBA 01/2018 - 10/2014
4	ThromboxanesIBA 02/2011 - 12/2003
3	CytokinesIBA 11/2020 - 05/2010
3	Epoprostenol (Prostacyclin)FDA LinkGeneric 10/2019 - 09/2002
3	Matrix Metalloproteinases (MMPs)IBA 01/2019 - 11/2016
3	riociguatIBA 01/2019 - 04/2011
3	TRPC6 Cation ChannelIBA 01/2017 - 05/2009
3	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 03/2016 - 11/2008
3	Soluble Guanylyl CyclaseIBA 06/2015 - 03/2009
3	Small Interfering RNA (siRNA)IBA 12/2013 - 04/2011
3	Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)IBA 06/2013 - 07/2010
3	Imatinib Mesylate (Gleevec)FDA Link 04/2011 - 11/2008
3	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 10/2010 - 11/2002
3	Epoxide HydrolasesIBA 05/2010 - 02/2009
3	Phosphodiesterase 5 InhibitorsIBA 10/2006 - 01/2004
3	Iloprost (Ventavis)FDA Link 12/2003 - 11/2002
2	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 03/2022 - 05/2010
2	Atrial Natriuretic Factor (ANF)IBA 02/2022 - 03/2016
2	Type 6 Cyclic Nucleotide PhosphodiesterasesIBA 01/2022 - 10/2010
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2022 - 07/2014
2	Cysteine (L-Cysteine)FDA Link 01/2022 - 08/2017
2	FibrinIBA 01/2022 - 12/2003
2	ProteomeIBA 01/2022 - 01/2017
2	CalciumIBA 01/2022 - 08/2017
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2022 - 01/2020
2	Pancreatic Elastase (Elastase)IBA 01/2021 - 12/2003
2	Tadalafil (Cialis)FDA Link 10/2020 - 10/2004
2	NADPH Oxidase 2IBA 01/2020 - 02/2014
2	indium-bleomycinIBA 10/2019 - 07/2010
2	Guanosine Monophosphate (5' Guanylic Acid)IBA 01/2019 - 01/2004
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2019 - 01/2012
2	LipidsIBA 01/2019 - 01/2010
2	Mitogen-Activated Protein KinasesIBA 01/2018 - 09/2014
2	Therapeutic UsesIBA 01/2017 - 06/2013
2	AngiotensinsIBA 03/2016 - 10/2014
2	Angiotensin IIIBA 03/2016 - 12/2013
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 11/2015 - 09/2008
2	Endothelin-1 (Endothelin 1)IBA 09/2014 - 06/2011
2	Diltiazem (Cardizem)FDA LinkGeneric 03/2014 - 12/2013
2	acetovanillone (apocynin)IBA 02/2014 - 03/2012
2	Messenger RNA (mRNA)IBA 12/2013 - 05/2004
2	LigandsIBA 12/2012 - 04/2011
2	Sodium Bicarbonate (Baking Soda)FDA LinkGeneric 01/2012 - 11/2009
2	Pharmaceutical PreparationsIBA 06/2011 - 04/2011
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 04/2011 - 01/2010
2	Tyrosine (L-Tyrosine)FDA Link 04/2011 - 11/2008

Therapy/Procedure

13	Therapeutics 01/2021 - 07/2003